Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.

Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide transport is instrumental in managing human contamination. Here we show that siderocalin, a mammalian siderophore-binding protein from the lipocalin family, specifically binds ...

متن کامل

Nanolipoparticles-mediated MDR1 siRNA delivery: preparation, characterization and cellular uptake

Objective(s): Lipid-based nanoparticles (NLP) are PEGylated carriers composed of lipids and encapsulated nucleic acids with a diameter less than 100 nm. The presence of PEG in the NLP formulation improves the particle pharmacokinetic behavior. The purpose of this study was to prepare and characterize NLPs containing MDR1 siRNA and evaluate their cytotoxicity and cellular uptake. MDR1 siRNA coul...

متن کامل

nanolipoparticles-mediated mdr1 sirna delivery: preparation, characterization and cellular uptake

objective(s): lipid-based nanoparticles (nlp) are pegylated carriers composed of lipids and encapsulated nucleic acids with a diameter less than 100 nm. the presence of peg in the nlp formulation improves the particle pharmacokinetic behavior. the purpose of this study was to prepare and characterize nlps containing mdr1 sirna and evaluate their cytotoxicity and cellular uptake. mdr1 sirna coul...

متن کامل

Receptor-mediated cellular uptake of cyclosporine.

THE PROCESS of cellular uptake and metabolism of cyclosporine (CsA) is poorly understood. Earlier studies in this laboratory indicated that transport of CsA in blood occurs in association with plasma lipoproteins, with low density lipoprotein (LDL) and high density lipoprotein (HOL) carrying about 32% each of the total CsA in blood. This observation suggests the possibility that the cellular up...

متن کامل

Efficiency of cellular uptake of nanoparticles via receptor-mediated endocytosis

Anand Banerjee, Alexander Berzhkovskii, and Ralph Nossal Program in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health, and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA Mathematical and Statistical Computing Laboratory, Division of Computational Bioscience, Center for Information Technology, National Institutes of Health, Bethesda, Mar...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 2015

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.1508902112